CD27 Antibody [O323] (APC-Cy7) Cat. No.: 76-629

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
TESTED APPLICATIONS: Flow
SPECIFICITY: The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG1, kappa
CONJUGATE:APC-Cy7
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:CD27
ALTERNATE NAMES:T14, S152, Tp55, TNFRSF7, S152. LPFS2, CD27
GENE ID:939
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.
REFERENCES:1) Hendriks, J., Xiao, Y., Borst, J. (2003). CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.The Journal of experimental medicine,198(9), 1369-1380.
2) Sakanishi, T., Yagita, H. (2010). Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications,393(4), 829-835.
3) Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995). Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7(4), 551-557.

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