CD24 Recombinant Protein Cat. No.: 11-274

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Ser 27 - Gly 59
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 5.0 kDa. The protein migrates as 19-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:5.0 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD24,CD24A
ACCESSION NO.:NP_001278666.1
OFFICIAL SYMBOL:CD24
GENE ID:100133941
psi-iconBackground and References
BACKGROUND:CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
REFERENCES:1) Suzuki T1, et al. 2001. J Immunol. 166(9):5567-77.
2) Chen Z, et al. 2017. Biomed Pharmacother. 90:427-436.
3) Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18(4):328-336.

FOR RESEARCH USE ONLY.

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