CD209 / DC-SIGN Recombinant Protein Cat. No.: 11-250

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 59 - Ala 404
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:41.3 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:DC-SIGN,CD209,DC-SIGN1,CLEC4L
ACCESSION NO.:NP_066978.1
OFFICIAL SYMBOL:CD209
GENE ID:30835
psi-iconBackground and References
BACKGROUND:CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
REFERENCES:1) Geijtenbeek TB, et al. 2000. Nat Immunol. 1(4):353-7.
2) Geijtenbeek TB, et al. 2000. Cell. 100(5):587-97.
3) Engering A, et al. 2002. J Immunol. 168(5):2118-26.

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