CD197 Antibody [3D12] (PE) Cat. No.: 76-932

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
TESTED APPLICATIONS: Flow
SPECIFICITY: The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG1, kappa
CONJUGATE:PE
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:CCR7
ALTERNATE NAMES:BLR2, EBI1, CCR-7, CD197, CDw197, CMKBR7, CC-CKR-7, CCR7
GENE ID:1236
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled. It is the receptor for the secondary lymphoid-tissue chemokine (SLC or 6CKine), CCL19, and CCL21. CD197 is expressed on subsets of B and T cells, and mature dendritic cells. The monoclonal 3D12 antibody recognizes the N-terminus of the receptor.
REFERENCES:1) Gattei, V., Godeas, C., Degan, M., Rossi, F. M., Aldinucci, D., Pinto, A. (1999). Characterization of anti‐CD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan‐1 in human lymphoma cells.British journal of haematology,104(1), 152-162.
2) Fitzgerald, M. L., Wang, Z., Park, P. W., Murphy, G., Bernfield, M. (2000). Shedding of syndecan-1 and-4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3sensitive metalloproteinase.The Journal of cell biology,148(4), 811-824.
3) Itoua Maga, R., Lemieux, J., Roy, A., Simard, C., Nron, S. (2014). Flow Cytometry Assessment of In Vitro Generated CD138.BioMed research international,2014.

ANTIBODIES FOR RESEARCH USE ONLY.

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