| HOST SPECIES: | Mouse |
| SPECIES REACTIVITY: | Human |
| TESTED APPLICATIONS: | Flow |
| SPECIFICITY: | The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. |
Specifications| PURIFICATION: | The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | Mouse IgG2b, kappa |
| CONJUGATE: | PE |
| PHYSICAL STATE: | liquid |
| BUFFER: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze. |
| OFFICIAL SYMBOL: | CCR3 |
| ALTERNATE NAMES: | CKR3, CD193, CMKBR3, CC-CKR-3, CCR3 |
| GENE ID: | 1232 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. CD193. CD193 is a G protein-coupled seven transmembrane receptor that binds to eotaxin-1,2,3 and to a lesser degree to MCP-3,4 and RANTES. It is expressed on eosinophils and basophils, mast cells platelets, CD34+ hematopoietic progenitor, and mononuclear phagocytes. CD193 plays a role in asthma and is a co-receptor for HIV-1,2. |
| REFERENCES: | 1) Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., ... Dejana, E. (1995). Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arteriosclerosis, thrombosis, and vascular biology,15(8), 1229-1239. | 2) Rajesh, D., Chinnasamy, N., Mitalipov, S. M., Wolf, D. P., Slukvin, I., Thomson, J. A., Shaaban, A. F. (2007). Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.Stem Cells,25(2), 490-499. | 3) Dejana, E., Bazzoni, G., Lampugnani, M. G. (1999). Vascular endothelial (VE)-cadherin: only an intercellular glue?.Experimental cell research,252(1), 13-19. |
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