| BACKGROUND: | The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. CD193. CD193 is a G protein-coupled seven transmembrane receptor that binds to eotaxin-1,2,3 and to a lesser degree to MCP-3,4 and RANTES. It is expressed on eosinophils and basophils, mast cells platelets, CD34+ hematopoietic progenitor, and mononuclear phagocytes. CD193 plays a role in asthma and is a co-receptor for HIV-1,2. |
| REFERENCES: | 1) Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., ... Dejana, E. (1995). Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arteriosclerosis, thrombosis, and vascular biology,15(8), 1229-1239. |
| 2) Rajesh, D., Chinnasamy, N., Mitalipov, S. M., Wolf, D. P., Slukvin, I., Thomson, J. A., Shaaban, A. F. (2007). Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.Stem Cells,25(2), 490-499. | | 3) Dejana, E., Bazzoni, G., Lampugnani, M. G. (1999). Vascular endothelial (VE)-cadherin: only an intercellular glue?.Experimental cell research,252(1), 13-19. |
Specifications
