CD193 Antibody [5E8-G9-B4] (PE) Cat. No.: 76-859

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
TESTED APPLICATIONS: Flow
SPECIFICITY: The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG2b, kappa
CONJUGATE:PE
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:CCR3
ALTERNATE NAMES:CKR3, CD193, CMKBR3, CC-CKR-3, CCR3
GENE ID:1232
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. CD193. CD193 is a G protein-coupled seven transmembrane receptor that binds to eotaxin-1,2,3 and to a lesser degree to MCP-3,4 and RANTES. It is expressed on eosinophils and basophils, mast cells platelets, CD34+ hematopoietic progenitor, and mononuclear phagocytes. CD193 plays a role in asthma and is a co-receptor for HIV-1,2.
REFERENCES:1) Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., ... Dejana, E. (1995). Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arteriosclerosis, thrombosis, and vascular biology,15(8), 1229-1239.
2) Rajesh, D., Chinnasamy, N., Mitalipov, S. M., Wolf, D. P., Slukvin, I., Thomson, J. A., Shaaban, A. F. (2007). Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.Stem Cells,25(2), 490-499.
3) Dejana, E., Bazzoni, G., Lampugnani, M. G. (1999). Vascular endothelial (VE)-cadherin: only an intercellular glue?.Experimental cell research,252(1), 13-19.

ANTIBODIES FOR RESEARCH USE ONLY.

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