CD19 Recombinant Protein Cat. No.: 96-141

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psi-iconSpecifications
SPECIES:Rhesus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Pro 20 - Lys 292
FUSION TAG:C-Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by reduced SDS-PAGE.

Less than 1.0 EU per μg by the LAL method.
PREDICTED MOLECULAR WEIGHT:56.7kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD19, B4, CVID3, MGC12802
ACCESSION NO.:F7F486
OFFICIAL SYMBOL:CD19
GENE ID:705211
psi-iconBackground and References
BACKGROUND:B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I  membrane protein and contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.
REFERENCES:1) Kozmik Z., et al., 1992, Mol. Cell. Biol. 12:2662-2672.
2) Kuroki K., et al., 2002, Genes Immun. 3:S21-S30.
3) Stamenkovic I., 1998, Seed B.J. Exp. Med. 168:1205-1210.

FOR RESEARCH USE ONLY.

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