CD19 Antibody [MB19-1] (APC-Cy7) Cat. No.: 98-675

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Mouse
IMMUNOGEN: CD19+ mouse pre-B cell line 300.19
TESTED APPLICATIONS: Flow, ICC, IP, WB
APPLICATIONS: CD19 Antibody [MB19-1] for use in flow cytometry assays.
SPECIFICITY: CD19

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgA
CONJUGATE:APC-Cy7
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Cd19
ALTERNATE NAMES:B4, Leu-12
ACCESSION NO.:P25918
GENE ID:12478
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow.

ANTIBODIES FOR RESEARCH USE ONLY.

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