| HOST SPECIES: | Rat |
| SPECIES REACTIVITY: | Mouse |
| TESTED APPLICATIONS: | Flow |
| SPECIFICITY: | The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. |
Specifications| PURIFICATION: | The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | Rat IgG2b, kappa |
| CONJUGATE: | PE |
| PHYSICAL STATE: | liquid |
| BUFFER: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze. |
| OFFICIAL SYMBOL: | Cxcr4 |
| ALTERNATE NAMES: | CD184, LESTR, Sdf1r, Cmkar4, PB-CKR, b2b220Clo, PBSF/SDF-1 |
| GENE ID: | 12767 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD184 is a coreceptor for X4 HIV-1.The monoclonal 2B11 antibody recognizes the amino terminus of CD184 and has functional activity. |
| REFERENCES: | 1) Pierelli, L., Bonanno, G., Rutella, S., Marone, M., Scambia, G., Leone, G. (2001). CD105 (endoglin) expression on hematopoietic stem/progenitor cells.Leukemia lymphoma,42(6), 1195-1206. | 2) She, X., Matsuno, F., Harada, N., Tsai, H., Seon, B. K. (2004). Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐-beta in suppression of growth of human endothelial cells.International journal of cancer,108(2), 251-257. | 3) Seon, B. K., Kumar, S. (2002). CD105 antibody for targeting of tumor vascular endothelial cells. InThe new angiotherapy(pp. 499-515). Humana Press. |
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