CD184 Antibody [2B11] (PE) Cat. No.: 76-871

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse
TESTED APPLICATIONS: Flow
SPECIFICITY: The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
CLONALITY:Monoclonal
ISOTYPE:Rat IgG2b, kappa
CONJUGATE:PE
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:Cxcr4
ALTERNATE NAMES:CD184, LESTR, Sdf1r, Cmkar4, PB-CKR, b2b220Clo, PBSF/SDF-1
GENE ID:12767
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD184 is a coreceptor for X4 HIV-1.The monoclonal 2B11 antibody recognizes the amino terminus of CD184 and has functional activity.
REFERENCES:1) Pierelli, L., Bonanno, G., Rutella, S., Marone, M., Scambia, G., Leone, G. (2001). CD105 (endoglin) expression on hematopoietic stem/progenitor cells.Leukemia lymphoma,42(6), 1195-1206.
2) She, X., Matsuno, F., Harada, N., Tsai, H., Seon, B. K. (2004). Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐-beta in suppression of growth of human endothelial cells.International journal of cancer,108(2), 251-257.
3) Seon, B. K., Kumar, S. (2002). CD105 antibody for targeting of tumor vascular endothelial cells. InThe new angiotherapy(pp. 499-515). Humana Press.

ANTIBODIES FOR RESEARCH USE ONLY.

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