CD16/32 Antibody [93] (PE-Cy5.5) Cat. No.: 98-746

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse
IMMUNOGEN: VH81X Tg B cells and T220 stromal cell line
TESTED APPLICATIONS: Adhesion, Depletion, ELISA, Flow, ICC, IHC-Fr, IP
APPLICATIONS: CD16/32 Antibody [93] for use in flow cytometry assays.
SPECIFICITY: CD16/32

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:PE-Cy5.5
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Fcgr2b; Fcgr3
ALTERNATE NAMES:FcRgammaII, FcRgammaIII, Fc gamma II receptor, Fc gamma III receptor, FcFR2, IGFR2, FcGR3, IGFR3, Fc receptor block
ACCESSION NO.:P08101; P08508
GENE ID:14130/14131
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The lymphocyte Fcgamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcgamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcgammaR+ cells, monoclonal antibodies to the FcgammaII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcgammaR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcgammaII and FcgammaIII receptors.

ANTIBODIES FOR RESEARCH USE ONLY.

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