CD155 Recombinant Protein Cat. No.: 96-841

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Trp 21 - Asn 343
FUSION TAG:mouse IgG2a Fc tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This recombinant protein can be used for E, WB. For research use only.
BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized Human TIGIT, Fc Tag at 2 ug/mL (100 uL/well) can bind Human CD155, mouse IgG2a Fc tag with a linear range of 0.98-7.81 ng/mL (QC tested).
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 0.1 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:62.2 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5
ACCESSION NO.:NP_006496.2
OFFICIAL SYMBOL:CD155
GENE ID:5817
psi-iconBackground and References
BACKGROUND:CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that is encoded by the PVR gene. CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.
REFERENCES:1) (1)Zhang P., et al., 2008, Proc. Natl. Acad. Sci., 105 (47): 18284-18289.
2) (2)Maier MK., et al., 2007, European Journal of Immunology, 37 (8): 2214-2225.
3) (3)He Y., et al., 2000, Proc. Natl. Acad. Sci., 97 (1): 79-84.

FOR RESEARCH USE ONLY.

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