| HOST SPECIES: | Mouse |
| SPECIES REACTIVITY: | Human |
| TESTED APPLICATIONS: | Flow |
| SPECIFICITY: | The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. |
Specifications| PURIFICATION: | The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | Mouse IgG1, kappa |
| CONJUGATE: | PE-Cy5 |
| PHYSICAL STATE: | liquid |
| BUFFER: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze. |
| OFFICIAL SYMBOL: | IL7R |
| ALTERNATE NAMES: | ILRA, CD127, IL7RA, CDW127, IL-7R-alpha, IL7R |
| GENE ID: | 3575 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. CD127 binds with CD132 (gamma c) to forms the IL-7 receptor that is expressed on mature T cells and immature B cells. Since CD127 expression is downregulated in Treg cells, it can be used as a marker for differentiating them from common T cells. The binding of the RDR5 antibody can be blocked by pre-incubating the cells with human IL-7. |
| REFERENCES: | 1) Sallusto, F., Lenig, D., Frster, R., Lipp, M., Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.Nature,401(6754), 708-712. | 2) Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... Yoshie, O. (1998). EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.International immunology,10(7), 901-910. | 3) Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lpez-Botet, M., Geraghty, D. E. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.Proceedings of the National Academy of Sciences,95(9), 5199-5204. |
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