| BACKGROUND: | The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123’s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells. |
| REFERENCES: | 1) Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S. (2009). Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.Journal of General Virology,90(3), 710-722. |
| 2) Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., ... Mackay, C. R. (1997). Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.Journal of Clinical Investigation,99(2), 178. | | 3) Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., ... Sodroski, J. (1996). The -beta--chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell,85(7), 1135-1148. |
Specifications
