| HOST SPECIES: | Mouse |
| SPECIES REACTIVITY: | Human |
| TESTED APPLICATIONS: | Flow |
| SPECIFICITY: | The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. |
Specifications| PURIFICATION: | The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | Mouse IgG1, kappa |
| CONJUGATE: | PE |
| PHYSICAL STATE: | liquid |
| BUFFER: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| CONCENTRATION: | batch dependent |
| STORAGE CONDITIONS: | The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze. |
| OFFICIAL SYMBOL: | IL3RA |
| ALTERNATE NAMES: | IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra, IL3RA |
| GENE ID: | 3563 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123’s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells. |
| REFERENCES: | 1) Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S. (2009). Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.Journal of General Virology,90(3), 710-722. | 2) Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., ... Mackay, C. R. (1997). Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.Journal of Clinical Investigation,99(2), 178. | 3) Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., ... Sodroski, J. (1996). The -beta--chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell,85(7), 1135-1148. |
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