CD11b Antibody [M1/70] (Cy5) Cat. No.: 98-649

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Baboon, Human, Mouse, Rabbit
IMMUNOGEN: C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
TESTED APPLICATIONS: ELISA, IP, WB
APPLICATIONS: CD11b Antibody [M1/70] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
SPECIFICITY: CD11b

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2b
CONJUGATE:Cy5
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Itgam
ALTERNATE NAMES:Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
ACCESSION NO.:P05555
GENE ID:16409
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.

ANTIBODIES FOR RESEARCH USE ONLY.

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