CD117 Antibody [2B8] (Cy5) Cat. No.: 99-020

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse
IMMUNOGEN: Mouse IL-3-dependent bone marrow mast cells
TESTED APPLICATIONS: Apoptosis, Flow, ICC, IHC-Fr, IP
APPLICATIONS: CD117 Antibody [2B8] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
SPECIFICITY: CD117

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2b
CONJUGATE:Cy5
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Kit
ALTERNATE NAMES:c-Kit, mast cell growth factor, stem cell factor, steel factor, SCF
ACCESSION NO.:P05532
GENE ID:16590
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.

ANTIBODIES FOR RESEARCH USE ONLY.

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