CD107b Antibody [H4B4] Cat. No.: 99-603

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: African green monkey, Human
IMMUNOGEN: Human adherent peripheral blood cells
TESTED APPLICATIONS: Flow
APPLICATIONS: CD107b Antibody [H4B4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and purification assays.
SPECIFICITY: CD107b

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:LAMP2
ALTERNATE NAMES:LAMP-2, lysosome-associated membrane protein 2
ACCESSION NO.:P13473
GENE ID:3920
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

ANTIBODIES FOR RESEARCH USE ONLY.

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