CD107a Antibody [H4A3] (PE) Cat. No.: 99-601

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: African green monkey, Human
IMMUNOGEN: Human adherent peripheral blood cells
TESTED APPLICATIONS: Complement Mediated Cell Depletion, Depletion, Flow, IHC-Fr, IP
APPLICATIONS: CD107a Antibody [H4A3] for use in flow cytometry assays.
SPECIFICITY: CD107a

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:PE
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:Lot specific
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:LAMP1
ALTERNATE NAMES:LAMP-1, lysosome-associated membrane protein 1
ACCESSION NO.:P11279
GENE ID:3916
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

ANTIBODIES FOR RESEARCH USE ONLY.

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