Specifications
| HOST SPECIES: | Mouse |
| SPECIES REACTIVITY: |
Human, Porcine |
| TESTED APPLICATIONS: |
Depletion, Flow, ICC, IHC, IP, Separation, Stimulation |
| APPLICATIONS: |
CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, adhesion, and blocking assays. |
| SPECIFICITY: |
CD106 |
Properties
| CLONALITY: | Monoclonal |
| ISOTYPE: | IgG1 |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added |
| CONCENTRATION: | 0.1 mg/mL |
| STORAGE CONDITIONS: | Store vial at 2-8˚C |
Additional Info
| OFFICIAL SYMBOL: | VCAM1 |
| ALTERNATE NAMES: | VCAM-1, INCAM-110, vascular cell adhesion molecule-1 |
| ACCESSION NO.: | P19320 |
| GENE ID: | 7412 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
ANTIBODIES FOR RESEARCH USE ONLY.
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