Datasheet

CCR7 Antibody
CATALOG NUMBER: 7649

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:CCR7 antibody can be used for detection of CCR7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1306 - Human Spleen Tissue Lysate
 2) Cat. No. 10-901 - Human Spleen Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 42 kDa

Observed: 42 kDa
SPECIFICITY:CCR7 antibody is human specific. CCR7 antibody is predicted to not cross-react with other CCR proteins.
IMMUNOGEN:CCR7 antibody was raised against a 15 amino acid peptide near the center of human CCR7.

The immunogen is located within amino acids 180 - 230 of CCR7.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CCR7 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CCR7 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CCR7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CCR7 Antibody: BLR2, EBI1, CD197, CDw197, CMKBR7, EVI1, C-C chemokine receptor type 7, BLR2, C-C CKR-7
ACCESSION NO.:NP_001829
PROTEIN GI NO.:4502641
OFFICIAL SYMBOL:CCR7
GENE ID:1236

Background

BACKGROUND:The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2). The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3).
REFERENCES: 1) Birkenbach M, Josefsen K, Yalamanchil R, et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 1993; 67:2209-20.
2) Forster R, Davalos-Misslitz AC, and Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008; 8:362-71.
3) Yoshida R, Imai T, Hieshima K, et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 1997; 272:13803-9.

For Research Use Only