The extracellular domain of mouse CCL22 (aa 25-92) is fused to the N-terminus of the Fc region of mouse IgG2a.
FUSION TAG:
Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:
This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY:
N/A
Properties
PURITY:
>98% (SDS-PAGE).
Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
PHYSICAL STATE:
Lyophilized
BUFFER:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
STORAGE CONDITIONS:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
Additional Info
ALTERNATE NAMES:
C-C Motif Chemokine 22, CC Chemokine STCP-1, Stimulated T Cell Chemotactic Protein 1, STCP1, MDC, Macrophage-derived Chemokine, Small-inducible Cytokine A22
ACCESSION NO.:
NP_033163
PROTEIN GI NO.:
6677879
OFFICIAL SYMBOL:
Ccl22
GENE ID:
20299
Background and References
BACKGROUND:
CCL22 (C-C Motif Chemokine 22; Stimulated T cell chemotactic protein; STCP1) is a CC chemokine initially isolated from clones of monocyte-derived macrophages and binds to the receptor CCR4. Human CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells and thymus. It is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. May play a role in the trafficking of activated/effector T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL-2 activated NK cells and activated T lymphocytes.
Specifications
