Datasheet

CCDC55 Antibody
CATALOG NUMBER: 6519

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (88%)
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:CCDC55 antibody can be used for detection of CCDC55 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
SPECIFICITY:At least three isoforms are known to exist; this antibody will detect all three.
IMMUNOGEN:CCDC55 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human CCDC55.

The immunogen is located within amino acids 430 - 480 of CCDC55.
HOST SPECIES:Chicken

Properties

PURIFICATION:CCDC55 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CCDC55 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CCDC55 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CCDC55 Antibody: CCDC55, NSrp70, HSPC095, CCDC55, NSRP70, Nuclear speckle splicing regulatory protein 1, Coiled-coil domain-containing protein 55
ACCESSION NO.:NP_115517
PROTEIN GI NO.:14149807
OFFICIAL SYMBOL:NSRP1
GENE ID:84081

Background

BACKGROUND:CCDC55 Antibody: CCDC55, also known as Nuclear speckle-related protein 70 (NSrp70), was initially identified by the NIH Mammalian Gene Collection. Nuclear speckles are known to be the storage sites of mRNA splicing regulators. CCDC55 has been suggested to modulate alternative pre-mRNA splicing in vivo. It co-localizes and physically interacts with the SR proteins SC35 and ASF/SF2, essential splicing factors which are required for constitutive splicing and can regulate alternative mRNA splicing. Loss of CCDC55 in mice leads to early embryonic lethality highlights the importance of the functional role of CCDC55.
REFERENCES: 1) Kim YD, Lee JY, Oh KM, et al. NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. Nuc. Acids Res. 2011; 39:4300-14.

For Research Use Only