CCDC55 Antibody Cat. No.: 6519

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psi-iconSpecifications
HOST SPECIES:Chicken
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (88%)
IMMUNOGEN: CCDC55 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human CCDC55.

The immunogen is located within amino acids 430 - 480 of CCDC55.
TESTED APPLICATIONS: ELISA, IF, WB
APPLICATIONS: CCDC55 antibody can be used for detection of CCDC55 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
SPECIFICITY: At least three isoforms are known to exist; this antibody will detect all three.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate

psi-iconProperties
PURIFICATION:CCDC55 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:CCDC55 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CCDC55 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:NSRP1
ALTERNATE NAMES:CCDC55 Antibody: CCDC55, NSrp70, HSPC095, CCDC55, NSRP70, Nuclear speckle splicing regulatory protein 1, Coiled-coil domain-containing protein 55
ACCESSION NO.:NP_115517
PROTEIN GI NO.:14149807
GENE ID:84081
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CCDC55 Antibody: CCDC55, also known as Nuclear speckle-related protein 70 (NSrp70), was initially identified by the NIH Mammalian Gene Collection. Nuclear speckles are known to be the storage sites of mRNA splicing regulators. CCDC55 has been suggested to modulate alternative pre-mRNA splicing in vivo. It co-localizes and physically interacts with the SR proteins SC35 and ASF/SF2, essential splicing factors which are required for constitutive splicing and can regulate alternative mRNA splicing. Loss of CCDC55 in mice leads to early embryonic lethality highlights the importance of the functional role of CCDC55.
REFERENCES:1) Kim YD, Lee JY, Oh KM, et al. NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. Nuc. Acids Res. 2011; 39:4300-14.

ANTIBODIES FOR RESEARCH USE ONLY.

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