Datasheet

CCDC22 Antibody
CATALOG NUMBER: 6933

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (100%)
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:CCDC22 antibody can be used for detection of CCDC22 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1210 - HEK293 Cell Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide
SPECIFICITY:At least three isoforms of CCDC22 are known to exist; this antibody will detect the two largest isoforms.
IMMUNOGEN:CCDC22 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC22.

The immunogen is located within amino acids 530 - 580 of CCDC22.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CCDC22 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CCDC22 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CCDC22 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CCDC22 Antibody: JM1, CXorf37, JM1, Coiled-coil domain-containing protein 22
ACCESSION NO.:NP_054727
PROTEIN GI NO.:7661844
OFFICIAL SYMBOL:CCDC22
GENE ID:28952

Background

BACKGROUND:CCDC22 Antibody: CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID).
REFERENCES: 1) Tomsig JL, Snyder SL, and Creutz CE. Identification of targets for calcium signaling through the copine family of proteins. J. Biol. Chem. 2003; 278:10048-54.
2) Mulder J, Bjorling E, Jonasson K, et al. Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. Mol. Cell Prot. 2009; 8:1612-22.
3) Mulder J, Wernerus H, Shi TJ, et al. Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system. Neurosci.2007; 146:1689-703
4) Voineagu I, Huang L, Winden K, et al. CCDC22: a novel candidate gene for syndromic X-linked intellectual disability. Mol. Psych. 2012; 17:4-7.

For Research Use Only