Datasheet

CCDC141 Antibody
CATALOG NUMBER: 6399

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1220 - SK-N-SH Cell Lysate
SPECIFICITY:At least four isoforms of CCDC141 are known to exist.
IMMUNOGEN:CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.

The immunogen is located within amino acids 40 - 90 of CCDC141.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CCDC141 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CCDC141 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CCDC141 Antibody: CAMDI, Coiled-coil domain-containing protein 141
ACCESSION NO.:NP_775919
PROTEIN GI NO.:299829223
OFFICIAL SYMBOL:CCDC141
GENE ID:285025

Background

BACKGROUND:CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
REFERENCES: 1) Fukuda T, Sugita S, Inatome R, et al. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J. Biol. Chem. 2010; 285:40554-61.

For Research Use Only