Caveolin-1 Antibody Cat. No.: 8219

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Horse: (100%), Sheep: (100%), Bovine: (100%), Pig: (100%), Chicken: (88%)
IMMUNOGEN: Caveolin-1 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human Caveolin-1.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: Caveolin-1 antibody can be used for detection of Caveolin-1 by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
SPECIFICITY: At least two isoforms of Caveolin-1 are known to exist; this antibody will detect only the largest isoform.
POSITIVE CONTROL:1) Cat. No. 1302 - Human Lung Tissue Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 20 kDa

Observed: 21 kDa

psi-iconProperties
PURIFICATION:Caveolin-1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Caveolin-1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Caveolin-1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:CAV1
ALTERNATE NAMES:Caveolin-1 Antibody: Caveolin-1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
ACCESSION NO.:NP_001744
PROTEIN GI NO.:15451856
GENE ID:857
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4).
REFERENCES:1) Glenney JR Jr. The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett. 1992; 314:45-8.
2) Wary KK, Mariotti A, Zurzolo C, et al. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 1998; 94:625-34.
3) Capozza F, Williams TM, Schubert W, et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am. J. Pathol. 2003; 162:2029-39.
4) Kim CA, Delepine M, Boutet E, et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J. Clin. Endocrinol. Metab. 2008; 93:1129-34.

ANTIBODIES FOR RESEARCH USE ONLY.

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