Caspase-3 Antibody [SB71b] (HRP) Cat. No.: 99-810

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
IMMUNOGEN: Recombinant human caspase-3
TESTED APPLICATIONS: FLISA, Flow, ICC, IHC-Fr, IHC-P, WB
APPLICATIONS: Caspase-3 Antibody [SB71b] for use in western blotting assays.
SPECIFICITY: Caspase-3

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:HRP
PHYSICAL STATE:Liquid
BUFFER:Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
CONCENTRATION:Lot specific
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:CASP3
ALTERNATE NAMES:SPP32, Yama, apopain
ACCESSION NO.:P42574
GENE ID:836
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-3 is one of the best characterized caspases in terms of specificity and function in apoptosis. It is a ubiquitously expressed protein in mammals and is highly prevalent in cells with lymphocytic origins, indicating a regulatory role in the immune system. Caspase-3 plays a critical role during embryonic development by inducing morphogenetic cell death in the mammalian brain and has also been linked to chromatin condensation, DNA fragmentation, and blebbing. The SB71b monoclonal antibody detects endogenous levels of full length caspase-3 (35 kDa) and the large fragment of caspase-3 resulting from cleavage (17 kDa).

ANTIBODIES FOR RESEARCH USE ONLY.

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