Caspase-2 Antibody [10C6] Cat. No.: 36-178

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Dog, Human, Monkey, Mouse, Rat
IMMUNOGEN: Recombinant human caspase-2 (p19 subunit).
TESTED APPLICATIONS: ELISA, Flow, ICC, IHC
APPLICATIONS: Flow Cytometry: (overexpressed in cell lines) . Immunocytochemistry: (10-20ug/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining) . Immunohistochemistry: (frozen sections). Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.

psi-iconProperties
PURIFICATION:>95% (SDS-PAGE)
CLONALITY:Monoclonal
ISOTYPE:IgG2a, kappa
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:CASP2
ALTERNATE NAMES:CASP-2; Protease ICH-1; Neural Precursor Cell Expressed Developmentally Down-regulated Protein 2; NEDD-2
ACCESSION NO.:P42575
PROTEIN GI NO.:83300977
GENE ID:835
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

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