Caspase-11 Antibody [4E11] Cat. No.: 36-183

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse, Rat
IMMUNOGEN: Recombinant mouse caspase-11 (p20 fragment).
TESTED APPLICATIONS: ELISA, Flow, IP, WB
APPLICATIONS: ELISA: (recombinant protein). Flow Cytometry: (overexpressed in cell lines). Immunoprecipitation: (1-5ug/ml). Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.

psi-iconProperties
PURIFICATION:>95% (SDS-PAGE)
CLONALITY:Monoclonal
ISOTYPE:IgG1, kappa
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:Casp4
ALTERNATE NAMES:Caspase-11 (mouse); Protease ICH-3 (mouse)
ACCESSION NO.:P70343
PROTEIN GI NO.:341940314
GENE ID:12363
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

ANTIBODIES FOR RESEARCH USE ONLY.

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