CALR Recombinant Protein Cat. No.: XW-RP3028

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:aa. 18-417
TESTED APPLICATIONS:ELISA, MS, WB
APPLICATIONS:This recombinant protein can be used for WB, ELISA, MS.
BIOLOGICAL ACTIVITY: N/A
psi-iconProperties
PURITY:~90%
PREDICTED MOLECULAR WEIGHT:46 kDa (Calculated)
PHYSICAL STATE:Liquid
BUFFER:10 mM Tris, pH 8.0, 0.002% NaN3, 3mM NaCl, 2.5mM
STORAGE CONDITIONS:Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:RO, CRT, SSA, cC1qR, HEL-S-99n, CRTC, Calreticulin, CRP55, ERp60
ACCESSION NO.:NP_004334
PROTEIN GI NO.:4757900
OFFICIAL SYMBOL:CALR
GENE ID:811
psi-iconBackground and References
BACKGROUND:Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
REFERENCES:1) Horibe,T., Matsui,H., Tanaka,M., Nagai,H., Yamaguchi,Y., Kato,K. and Kikuchi,M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323 (1), 281-287 (2004)

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