Datasheet

BTLA Antibody
CATALOG NUMBER: 7473

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μg/ml.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
 2) Cat. No. 11-801 - Human Small Intestine Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 32 kDa

Observed: 40kDa
SPECIFICITY:BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.
IMMUNOGEN:BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA.

The immunogen is located within amino acids 170 - 220 of BTLA .
HOST SPECIES:Rabbit

Properties

PURIFICATION:BTLA Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:BTLA Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:BTLA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
ACCESSION NO.:NP_861445
PROTEIN GI NO.:145580621
OFFICIAL SYMBOL:BTLA
GENE ID:151888

Background

BACKGROUND:The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).
REFERENCES: 1) Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.
2) Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.
3) Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.

For Research Use Only