BTLA (31-150) Recombinant Protein Cat. No.: 11-243

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Lys 31 - Ser 150
FUSION TAG:Mouse IgG Fc Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:40.6 kDa
PHYSICAL STATE:Lyophilized
BUFFER:100 mM Glycine, 150 mM NaCl, Arginine, pH3.2
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:BTLA,CD272
ACCESSION NO.:AAP44003.1
OFFICIAL SYMBOL:BTLA
GENE ID:151888
psi-iconBackground and References
BACKGROUND:B- and T-lymphocyte attenuator (BTLA) is also known as B- and T-lymphocyte-associated protein, CD antigen CD272. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA / CD272 can interact with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, and interact with TNFRSF14/HVEM.
REFERENCES:1) Watanabe N., et al., 2003, Nat. Immunol. 4:670-679.
2) Gavrieli M., et al., 2003, Biochem. Biophys. Res. Commun. 312:1236-1243.
3) Sedy J.R., et al., 2005, Nat. Immunol. 6:90-98.

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