BMPR2 Antibody, KO Validated Cat. No.: 18-269

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2 (NP_001195.2).
TESTED APPLICATIONS: IF, WB
APPLICATIONS: WB: ,1:500 - 1:2000

IF: ,1:50 - 1:200
POSITIVE CONTROL:1) HeLa
PREDICTED MOLECULAR WEIGHT: Observed: 100kDa
psi-iconAdvanced Validation
VALIDATION: Antibody is Knockout validated.

psi-iconProperties
PURIFICATION:Affinity purification
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS:Store at -20˚C. Avoid freeze / thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:BMPR2
ALTERNATE NAMES:BMPR2, bone morphogenetic protein receptor, type II (serine/threonine kinase), BMPR-II, BMPR3, BMR2, BRK-3, FLJ76945, PPH1, T-ALK, TRG10, bone morphogenetic protein receptor type II, primary pulmonary hypertension 1, serine/threonine kinase, transformatio
GENE ID:659
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.