| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-408 of human BMP4 (NP_570912.2). |
| TESTED APPLICATIONS: | IF, IHC, WB |
| APPLICATIONS: | WB: ,1:500 - 1:2000 IHC: ,1:50 - 1:200 IF: ,1:50 - 1:200 |
Specifications| PURIFICATION: | Affinity purification |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| STORAGE CONDITIONS: | Store at -20˚C. Avoid freeze / thaw cycles. |
| OFFICIAL SYMBOL: | BMP4 |
| ALTERNATE NAMES: | Bone morphogenetic protein, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP-4, ZYME, OFC11, BMP2B1, MCOPS6 |
| GENE ID: | 652 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. |
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