BMP15 Antibody Cat. No.: 6909

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (75%), Sheep: (75%)
IMMUNOGEN: BMP15 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BMP15.

The immunogen is located within amino acids 30 - 80 of BMP15.
TESTED APPLICATIONS: ICC, IF
APPLICATIONS: BMP15 antibody can be used for detection of BMP15 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
SPECIFICITY: It is closely related to GDF9.
POSITIVE CONTROL:1) Cat. No. 1313 - Human Testis Tissue Lysate
 2) Cat. No. 17-201 - 3T3/BALB Cell Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 45 kDa

Observed: 50 kDa

psi-iconProperties
PURIFICATION:BMP15 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:BMP15 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:BMP15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:BMP15
ALTERNATE NAMES:BMP15 Antibody: ODG2, POF4, GDF9B, Bone morphogenetic protein 15, BMP-15
ACCESSION NO.:NP_005439
PROTEIN GI NO.:257743454
GENE ID:9210
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:BMP15 Antibody: BMP15, or GDF9B is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily that are involved in embryonic development and adult tissue homeostasis. BMP15 is expressed exclusively in the oocyte. It is an oocyte-specific growth/differentiation factor that may be involved in oocyte maturation and follicular development. Defects in BMP15 are the cause of ovarian dysgenesis type 2. BMP15 could be used as an oogenesis marker to track human amniotic fluid stem cells differentiation into the oocyte-like cells.
REFERENCES:1) Massagué J. The transforming growth factor-beta family. Ann. Rev. Cell. Biol. 1990; 6:597-641
2) Aaltonen J, Laitinen MP, Vuojolainen K, et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early foliculogenesis. J. Clin. Endocrinol. Metab. 1999; 84:2744-50.
3) Laitinen M, Vuojolainen K, Jaatinen R, et al. A novel growth differentiation factor-9 (GDF-9) related factor is coexpressed with GDF-9 in mouse oocytes during folliculogenesis. Mech. Dev. 1998; 78:135-40.
4) Galloway SM, Gregan SM, Wilson T et al. Bmp15 mutations and ovarian function. Mol. Cell Endocrinol. 2002; 191:15-8.

ANTIBODIES FOR RESEARCH USE ONLY.

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