Datasheet

BMP15 Antibody
CATALOG NUMBER: 4739

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Mouse: (89%), Sheep: (83%), Bovine: (83%)
TESTED APPLICATIONS:ELISA, IHC-P
APPLICATIONS:BMP15 antibody can be used for detection of BMP15 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 10-635 - Human Prostate Tissue Slide
PREDICTED MOLECULAR WEIGHT:43 kDa
IMMUNOGEN:Rabbit polyclonal BMP15 antibody was raised against an 18 amino acid peptide near the amino terminus of human BMP15.

The immunogen is located within amino acids 60 - 110 of BMP15.
HOST SPECIES:Rabbit

Properties

PURIFICATION:BMP15 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:BMP15 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:BMP15 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:BMP15 Antibody: ODG2, POF4, GDF9B, Bone morphogenetic protein 15, BMP-15
ACCESSION NO.:NP_005439
PROTEIN GI NO.:257743454
OFFICIAL SYMBOL:BMP15
GENE ID:9210

Background

BACKGROUND:BMP15 Antibody: BMP15, or GDF9B is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily that are involved in embryonic development and adult tissue homeostasis. BMP15 is expressed exclusively in the oocyte. It is an oocyte-specific growth/differentiation factor that may be involved in oocyte maturation and follicular development. Defects in BMP15 are the cause of ovarian dysgenesis type 2. BMP15 could be used as an oogenesis marker to track human amniotic fluid stem cells differentiation into the oocyte-like cells.
REFERENCES: 1) Massague J. The transforming growth factor-beta family. Ann. Rev. Cell. Biol. 1990; 6:597-641
2) Aaltonen J, Laitinen MP, Vuojolainen K, et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early foliculogenesis. J. Clin. Endocrinol. Metab. 1999; 84:2744-50.
3) Laitinen M, Vuojolainen K, Jaatinen R, et al. A novel growth differentiation factor-9 (GDF-9) related factor is coexpressed with GDF-9 in mouse oocytes during folliculogenesis. Mech. Dev. 1998; 78:135-40.
4) Galloway SM, Gregan SM, Wilson T et al. Bmp15 mutations and ovarian function. Mol. Cell Endocrinol. 2002; 191:15-8

For Research Use Only