BMP-6 Recombinant Protein Cat. No.: 40-204

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC - 5 cells. The expected ED50this effect is 0.03 - 0.06 μg/mL.
psi-iconProperties
PURITY:Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized BMP-6 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted BMP-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing BMP-6 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:VGR, VGR1, VGR, Bone morphogenetic protein 6, VG-1-related protein, BMP-6
ACCESSION NO.:NP_001709.1
PROTEIN GI NO.:4502425
OFFICIAL SYMBOL:BMP6
GENE ID:654
psi-iconBackground and References
BACKGROUND:TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

FOR RESEARCH USE ONLY.

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