BMP-4 Recombinant Protein Cat. No.: 40-203

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HeLa cells
SEQUENCE:HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
psi-iconProperties
PURITY:Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized BMP-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted BMP-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing BMP-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP-4
ACCESSION NO.:NP_001193.2
PROTEIN GI NO.:157276593
OFFICIAL SYMBOL:BMP4
GENE ID:652
psi-iconBackground and References
BACKGROUND:Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

FOR RESEARCH USE ONLY.

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