This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY:
Corresponding to a specific activity of 20000 IU/mg. The ED50 as determined by the cytolysis of MC3T3-E1 cells is <50 ng/mL.
Properties
PURITY:
>92% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:
13 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
0.1M acetic acid, pH2.0
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Additional Info
ALTERNATE NAMES:
BMP2, BMP2A
ACCESSION NO.:
NP_001191
OFFICIAL SYMBOL:
BMP2
GENE ID:
650
Background and References
BACKGROUND:
Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.
REFERENCES:
1) Lai, T.H. et al., (2008) Prostate. 68: 1341-1353.
Specifications
