ProSci Incorporated is Proud to announce that it has been selected as the 2022 Bioz Stars Award Winner in the COVID-19 Category. November 14, 2022 – San Diego, California, United States – ProSci Incorporated is… Read More
Understanding Inflammasomes
What is an inflammasome? An inflammasome is a formation of danger-sensing proteins when a cell becomes infected or damaged and is typically there to regulate the activation of caspase-1 and activate inflammation when host proteins… Read More
Bone Marrow Hematopoiesis Drives Multiple Sclerosis Progression
https://www.cell.com/cell/fulltext/S0092-8674(22)00651-1 Multiple sclerosis (MS) is categorized as an autoimmune disease where T cells attack the central nervous system and cause inflammation in the brain. New evidence shows that the bone marrow is a facilitator that… Read More
Highly Contagious Influenza Virus
As of May 2022, a highly contagious influenza virus continues to wreak havoc on domestic bird flocks across the United States. Millions of chickens and other fowl are dying or being killed to stop the… Read More
Single Domain Antibodies: Tools for the Future?
There are many ways single domain antibodies (sdAbs) — also known as Nanobodies™, VHH antibodies, and camelid antibodies are superior to conventional antibodies. Read on to find out how these unique antibodies can enhance your… Read More
SARS-CoV-2 protease Mpro (NSP5), a key to COVID-19 therapy?
Pfizer announced promising clinical trials for their drug Paxlovid (Owen et al., 2021), an inhibitor of the main SARS-CoV-2 protease, Mpro (3CLpro, NSP5). In addition to being the main SARS-CoV-2 protease, Liu et al., (2021)… Read More
SARS-CoV-2 Virus-like Particles (VLPs)
ProSci applauds the work described in two recent publications regarding the synthesis, production, and utility of SARS-CoV-2 virus-like particles (VLPs). Naskalska et al. (2021) (DOI: 10.3389/fmicb.2021.732998) created recombinant His-tagged forms of SARS-CoV-2 structural proteins that… Read More
SARS-CoV-2 Infection in Children
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children Loske et al. (2021) https://www.nature.com/articles/s41587-021-01037-9 The recent study by Loske et al (2021) investigated why children have reduced severe acute respiratory… Read More
SARS-CoV-2 (COVID-19) Mutations
As viruses create more of themselves within a host, they are prone to copying errors. These mutations or recombinations are single-point changes in the virus’ genetic code. Most of these changes do nothing, but others… Read More
The Effect of SAR-CoV-2 Vaccine Lasts At Least 4 Months
N Engl J Med reported the durability of immunity response of SARS-CoV-2 vaccine, mRNA-1273 (Moderna). The data was from 34 healthy adults with two vaccine injections. They have performed RBD binding assay and antibody neutralization… Read More