A Possible Vaccine for Dengue VirusDengue Virus

Vaccine research has shown that infecting volunteers with a weakened form of the dengue virus is able to boost the immune system enough to prevent future infections. This method of vaccination using weakened dengue virus, called the “human challenge” method, has not been used very often within the last century due to the risk it can pose for volunteers who are deliberately infected. The great success of this study of dengue has also given hops to those performing research on Zika. Dengue and Zika are both part of the flaviviridae family of viruses, and are similar in many aspects. It is possible that a similar treatment with the use of weakened Zika virus could be used to generate a Zika vaccine.
HIV Antibodies

 

 

Anti-HIV Antibodies “Cure” an Infected Monkey within Days

An HIV study showed use of a specific neutralizing monoclonal antibody (NmAb) can be used to treat newborn rhesus macaques that were exposed to the simian-human immunodeficiency virus (SHIV), which serves as a model for HIV. This paper shows that treatment with these neutralizing monoclonal antibodies could prevent mother-to-child transmission of HIV. Most importantly, this paper shows that early treatment of HIV with these neutralizing monoclonal antibodies can completely prevent long term HIV infection. Check out ProSci's own HIV research here.T-cells and tumor

 Immune Activity in Tumors is Increased by Neutralizing Acidity

Neutralizing the acidity of a tumor’s environment allows for a greater concentration of T-cells to survive inside tumor tissue. Tumor environments are more acidic due to the lack of blood vessels present in the newest tissue. This acidic environment can be toxic to T-cells, and normally prevents them from surviving in the area. This study showed that treating a tumor with sodium bicarbonate leads to a higher concentration of T-cells present in the tumors. This will be useful for bolstering immunotherapy treatments by allowing a greater concentration of T-cells to attack disabled tumor cells.

 ProSci is Introducing Isolated Plasma Cell Technology

As of the last week of March, ProSci has launched its rabbit monoclonal antibody services, using isolated plasma cell (IPC) technology. Rabbit monoclonal antibodies provide a major advantage, often characterized with a 10-100x greater affinity to antigens than their mouse monoclonal antibody counterparts. In addition, IPC technology uses pure plasma cell cultures to generate your monoclonal antibody, unlike B-cell cultures which only offer 0.1-1.0% plasma cells. With a wider variety of plasma cells, you are more likely to get the perfect antibody for your project, and you’ll receive it faster than those using hybridoma or phage display technologies. You may inquire about our rabbit monoclonal services here, and find out if they are right for you.

Rabbit Monoclonal Antibody

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