ProSci research HIV vaccineThe Start of ProSci

In 1984, human immunodeficiency virus type 1(HIV-1) was first discovered to be the cause of Acquired Immune Deficiency Syndrome(AIDS) pandemic, a fatal disease with 7,239 cases and 5,596  deaths reported at the time. This discovery and the impact the disease had on the world initiated efforts to create a vaccine against HIV to eliminate AIDS and inspired our graduate student experts, at the time to research this field. 

In 2001, ProSci Inc supported by grants from NIH Small Business Innovation Research (SBIRs), International AIDS Vaccine (IAVI), and Bill and Melinda Gates Foundation (BMGF) and partnered with the University of Pennsylvania, Department of Microbiology started research on developing a vaccine for HIV.

 

Our HIV Vaccine Research

The human immunodefiency virus type 1 (HIV-1) envelope (Env) protein contains a glycan shield composed of numerous N-linked carbohydrates which has become a popular target for HIV-1 vaccine design due to its critical role in transmission and infection, as well as the conservation of the region despite constant mutations that occur in HIV-1. In order to develop an HIV-1 vaccine immunogen to target this region, ProSci Antibody Experts have used a genetic approach of modifying baking yeast to express glycoproteins similar to HIV-1 which has had success in binding, generating antibodies, and containing neutralization activity under certain conditions. Our latest publication provides details on our research regarding the success, as well as the challenges of dealing with the different conformations HIV glycoproteins have in their native environment.

ProSci HIV experts

What’s Next in glycoprotein?

ProSci, with the help of local experts in glycoprotein at Scripps Research Institute, will continue working on improving our techniques and immunization strategies in order to increase immune response on glycan-specific or glycan-dependent neutralizing epitopes. The ultimate goal is to create a vaccine for HIV, however more research needed in order to accomplish this goal.