BLK Antibody [9D10D1] Cat. No.: 32-116

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
IMMUNOGEN: Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3).
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: Western Blot:1:500 - 1:2,000
IHC(P)1:500 - 1:2,000
IHC(F)1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:Unconjugated
BUFFER:Ascitic fluid containing 0.03% sodium azide.
STORAGE CONDITIONS:BLK monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:BLK
ALTERNATE NAMES:B lymphocyte kinaseMODY11
ACCESSION NO.:P51451
PROTEIN GI NO.:158936749
GENE ID:640
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
REFERENCES:1) Theresa Tretter, Ashley E. Ross, Dominic I. Dordai. J. Exp. Med., Dec 2003; 198: 1863.

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