Datasheet

Betatrophin Antibody
CATALOG NUMBER: 7619

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:Betatrophin antibody can be used for detection of Betatrophin by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 22 kDa

Observed: 22 kDa
SPECIFICITY:Betatrophin antibody is human, mouse and rat reactive. At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.
IMMUNOGEN:Betatrophin antibody was raised against a 16 amino acid peptide near the amino terminus of human Betatrophin.

The immunogen is located within amino acids 40 - 90 of Betatrophin.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Betatrophin antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:Betatrophin antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Betatrophin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Betatrophin Antibody: RIFL, TD26, ANGPTL8, PRO1185, PVPA599, Angptl8, UNQ599/PRO1185, Betatrophin, Angiopoietin-like protein 8
ACCESSION NO.:NP_061157
PROTEIN GI NO.:291219911
OFFICIAL SYMBOL:C19orf80
GENE ID:55908

Background

BACKGROUND:The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels (1,2). Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis (3).
REFERENCES: 1) Ren G, Kim JY, and Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am. J. Endocrinol. Metab. 2012; 303:E334-51.
2) Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem. Biophys. Res. Commun. 2012; 424:786-92.
3) Fu Z, Yao F, Abou-Samra AB, et al. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem. Biophys. Res. Commun. 2013; 430:1126-31.

For Research Use Only