Betacellulin Recombinant Protein Cat. No.: 40-578

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psi-iconSpecifications
SPECIES:Murine
SOURCE SPECIES:E. coli
SEQUENCE:DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is ≤ 0.01 ng/mL, corresponding to a specific activity of ≥ 1 x 108 units/mg. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
psi-iconProperties
PURITY:Greater than 98% by SDS-PAGE gel and HPLC analyses.
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized Betacellulin recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Betacellulin stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Betacellulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:Bcn, Bcn, Probetacellulin, BTC
ACCESSION NO.:NP_031594.1
PROTEIN GI NO.:6680812
OFFICIAL SYMBOL:Btc
GENE ID:12223
psi-iconBackground and References
BACKGROUND:Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

FOR RESEARCH USE ONLY.

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