beta-Pix Antibody Cat. No.: 36-195

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: Recombinant beta-Pix SH3 domain.
TESTED APPLICATIONS: ELISA, ICC, WB
APPLICATIONS: ELISA: (direct and indirect: 1:5,000-1:10,000). Immunocytochemistry: (1:1,000). Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes the multiple splice variants of human, mouse and rat beta-Pix a, b, bL, c and d-isoforms. Cross-reacts with human and rat beta-Pix.

psi-iconProperties
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:Arhgef7
ALTERNATE NAMES:Rho Guanine Nucleotide Exchange Factor 7; PAK-interacting Exchange Factor beta; p85SPR; COOL-1
ACCESSION NO.:Q9ES28
PROTEIN GI NO.:125987791
GENE ID:54126
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:beta-PIX acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. It interacts with PAK kinases through the SH3 domain. It may function as a positive regulator of apoptosis and is involved in cell migration. It is expressed with high levels in the central nervous system.

ANTIBODIES FOR RESEARCH USE ONLY.

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