Beclin-1 Recombinant Protein Cat. No.: 90-320

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:Recombinant human beclin-1 (aa 1-450) is fused through a thrombin linker to 6 x His-tag.
FUSION TAG:His Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: N/A
psi-iconProperties
PURITY:>85% (SDS-PAGE)
PHYSICAL STATE:Lyophilized
BUFFER:Lyophilized from 25mM TRIS-HCl, pH 8.0, containing 100mM glycine. Reconstitute in 100 μl sterile water.
CONCENTRATION:0.1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:ATG6, BECN1, GT197
ACCESSION NO.:NM_003766
PROTEIN GI NO.:929524265
OFFICIAL SYMBOL:BECN1
GENE ID:8678
psi-iconBackground and References
BACKGROUND:Beclin-1 (Bcl-2 interacting coiled-coil protein; ATG6) is a multifunctional protein, well-known as a key regulator of autophagy and required for the initiation step in autophagosome formation. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP3R, PINK and survivin) to regulate the lipid kinase PI3K protein and promote formation of PIK3C3/VPS34-containing complexes. These interactions induce autophagy, which is a process of programmed cell survival increased during periods of cell stress and extinguished during the cell cycle. Furthermore, beclin-1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, infection, tumorigenesis, aging and cell death. Beclin-1 is tightly regulated by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications and protein-protein interactions. Multiple diseases are associated with deficiency or malfunction of beclin-1, including cancer and neurodegeneration.

FOR RESEARCH USE ONLY.

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