| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (NP_733928.1). |
| TESTED APPLICATIONS: | IF, IHC, WB |
| APPLICATIONS: | WB: ,1:500 - 1:2000 IHC: ,1:50 - 1:200 IF: ,1:50 - 1:200 |
| POSITIVE CONTROL: | 1) A-549 |
| 2) SW480 | |
| 3) Mouse kidney | |
| 4) Mouse brain | |
| 5) Rat brain | |
| PREDICTED MOLECULAR WEIGHT: | Observed: 14kDa |
Specifications| PURIFICATION: | Affinity purification |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| STORAGE CONDITIONS: | Store at -20˚C. Avoid freeze / thaw cycles. |
| OFFICIAL SYMBOL: | BDNF |
| ALTERNATE NAMES: | BDNF , brain-derived neurotrophic factor, MGC34632, neurotrophin |
| GENE ID: | 627 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. |
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