Datasheet

BCL3 Antibody
CATALOG NUMBER: 7183

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:BCL3 antibody can be used for detection of BCL3 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1210 - HEK293 Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 50 kDa
IMMUNOGEN:Rabbit polyclonal BCL3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human BCL3.

The immunogen is located within amino acids 360 - 410 of BCL3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:BCL3 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:BCL3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3
ACCESSION NO.:NP_005169
PROTEIN GI NO.:164664508
OFFICIAL SYMBOL:BCL3
GENE ID:602

Background

BACKGROUND:BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ-B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ-B proteins. The expression of this gene can be induced by NF-κ-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ-B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.
REFERENCES: 1) Ohno H, Takimoto G, and McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990; 60:991-7.
2) Wulczyn FG, Naumann M, and Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 1992; 358:597-9.
3) Ibrahim HA, Amen F, Reid AG, et al. BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma. Eur. J. Haematol. 2011; 87:480-5.
4) Ge B, Li O, Wilder P, et al. NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J. Immunol. 2003; 171:4210-8.

For Research Use Only