BCL2L1 Recombinant Protein Cat. No.: 96-056

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:Met 1 - Arg 212
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized human BID protein at 10μg/ml (100μl/well) can bind biotinylated human BCL2L1 protein, The EC50 of biotinylated human BCL2L1 is 6. 5 ng/mL.
psi-iconProperties
PURITY:>92% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:24.6 kDa
PHYSICAL STATE:Lyophilized
BUFFER:20mM HEPES, 50mM KCl, pH 7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS
ACCESSION NO.:AAH19307
OFFICIAL SYMBOL:BCL2L1
GENE ID:598
psi-iconBackground and References
BACKGROUND:Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
REFERENCES:1) Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
2) Wang J., et al., 2011, Cell. Signal. 23:2030-2038.

FOR RESEARCH USE ONLY.

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