Bcl-xL Antibody [7B2.5] (FITC) Cat. No.: 99-617

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: Recombinant human Bcl-xS
TESTED APPLICATIONS: Flow
APPLICATIONS: Bcl-xL Antibody [7B2.5] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.
SPECIFICITY: Bcl-xL

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG3
CONJUGATE:FITC
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:BCL2L1
ALTERNATE NAMES:Apoptosis regulator Bcl-X, Bcl-2-like 1 protein, BCL2L1
ACCESSION NO.:Q07817
GENE ID:598
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Bcl-xL is a 29 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. It is found in both soluble and membrane fractions of cellular lysates. Like Bcl-2, Bcl-xL has been demonstrated to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. While formation of heterodimers with the apoptosis-enhancing protein, Bax does not block the apoptosis-suppressing property of Bcl-xL, heterodimerization with Bad effectively inhibits the protective function of Bcl-xL.

ANTIBODIES FOR RESEARCH USE ONLY.

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